Sonoeyes Blog

Congenital chloride diarrhea (CCD) is a rare, genetically inherited disorder characterized by chronic, life-threatening watery diarrhea due to excessive chloride loss in stools. It follows an autosomal recessive inheritance pattern, meaning both parents must be carriers of the defective gene for the condition to manifest in their child. While CCD is found worldwide, it has a higher prevalence in Finland and the Middle East. The condition was first described in 1945 by Gamble et al. and Darrow. More recent genetic studies have precisely located the responsible gene, SLC26A3, on chromosome 7. Meconium stained amniotic fluid Prenatal Indicators and Diagnosis Most affected infants are born preterm. Antenatal ultrasound findings typically include polyhydramnios and significant dilation of fetal intestinal loops, indicating abnormal fetal gastrointestinal function. Postnatally, CCD presents with severe abdominal distension, profuse watery diarrhea, and failure to th...

Fetal meconium peritonitis (MP) is a rare condition characterized by inflammation of the fetal abdominal cavity due to the leakage of meconium—the fetus's first intestinal discharge—into the peritoneal cavity. This leakage typically results from an intrauterine bowel perforation. While MP occurs infrequently, understanding its clinical presentation, diagnostic methods, and potential outcomes is crucial for expectant parents and healthcare providers. Causes and Pathophysiology The primary cause of MP is fetal bowel perforation, which can result from several underlying conditions: Bowel Obstruction: Congenital obstructions, such as intestinal atresia or stenosis, can lead to increased intraluminal pressure and subsequent perforation. Meconium Ileus: Often associated with cystic fibrosis, thickened meconium can obstruct the bowel, leading to perforation and peritonitis. Infections: Intrauterine infections may weaken the bowel wall, increasing the risk of perforation. Once meconium l...