Fetal diarrhoea

Congenital chloride diarrhea (CCD) is a rare, genetically inherited disorder characterized by chronic, life-threatening watery diarrhea due to excessive chloride loss in stools. It follows an autosomal recessive inheritance pattern, meaning both parents must be carriers of the defective gene for the condition to manifest in their child. While CCD is found worldwide, it has a higher prevalence in Finland and the Middle East. The condition was first described in 1945 by Gamble et al. and Darrow. More recent genetic studies have precisely located the responsible gene, SLC26A3, on chromosome 7. Meconium stained amniotic fluid Prenatal Indicators and Diagnosis Most affected infants are born preterm. Antenatal ultrasound findings typically include polyhydramnios and significant dilation of fetal intestinal loops, indicating abnormal fetal gastrointestinal function. Postnatally, CCD presents with severe abdominal distension, profuse watery diarrhea, and failure to th...